Sarcoma Cancer Treatment in Mumbai, India

Sarcoma is cancer that begins in the body's connective tissues like bones (bone sarcoma) and other soft tissues (called soft tissue sarcoma) like muscles, fat cells, blood vessels, tendons, and nerves. There are over 70 types of sarcoma. The treatment varies based on the type of the sarcoma; its location, stage, spread; and the overall age of the patient.

Sarcomas are rare, and according to the American Society of Clinical Oncology (ASCO), sarcomas account for just 1% of all adult cancers. However, sarcomas are relatively more common in children and makeup 15% of childhood cancers. Around 60% of sarcomas begin in the arm or the leg, while 30% begin in the abdomen. Only 10% of sarcomas start in the head and neck region.

The five-year survival rate for soft tissue sarcomas is 80%. However, the prognosis depends upon the type and stage of cancer at the time of diagnosis and the cancer’s response to treatments.

Sarcoma Cancer Symptoms

While the signs of cancer are objective or physically observable manifestations, symptoms are subjective experiences. The most common signs and symptoms of sarcoma are:

• A lump or growth under the skin
• Bone pain
• Sudden fracture or broken bone even with a minor injury
• Pain in the abdomen
• Unexpected or unintended weight loss
• Limited range of joint movement
• Fever of no known cause

Sarcoma Cancer Causes and Risk Factors

The exact reason why sarcomas occur is unknown. Like most cancers, sarcomas occur when abnormal changes (mutations) occur in the cells. These mutations prompt these cells to grow, divide and multiply uncontrollably, leading to cancer. Sarcomas may occur without any family history. Some suggested risk factors of this cancer are:

• Previous History of Radiation Therapy: People who have undergone radiation therapy for another cancer have a higher tendency to develop sarcoma.
• Genetic Conditions: Like most cancers, genetics can increase sarcoma risk. People with conditions like neurofibromatosis and tuberous sclerosis have an increased sarcoma risk.
• Chemical Exposure: Though research is still underway in this regard, exposure to industrial chemicals like vinyl chloride, and dioxins phenoxy acetate-containing herbicides can cause sarcoma.
• Human Herpes Virus 8: Kaposi’s sarcoma, caused by the Herpes Simplex Virus 8, can increase one’s risk of developing soft tissue sarcoma.
• Lymphedema: Lymphedema is a chronic swelling caused by a backup of lymph due to a blockage in the lymphatic system. This condition can increase one’s risk of developing angiosarcoma or sarcoma of the blood vessels.

Sarcoma Cancer Types

As mentioned earlier, sarcomas are primarily of two types – bone sarcomas and soft tissue sarcomas.

Types of bone sarcomas include:

• Osteosarcoma: Begins in the bones and affects bone cells.
• Ewing’s Sarcoma: Though more common in the bone, this type of sarcoma can also occur in soft tissues.
• Chondrosarcoma: As the name suggests, this type of sarcoma begins in the cartilage.
• Fibrosarcoma: This is a rare form of sarcoma that specifically occurs in bones.

Types of soft tissue sarcomas depend upon where the sarcoma begins. These include:

• Angiosarcoma
• Liposarcoma
• Leiomyosarcoma
• Neurofibrosarcoma
• Rhabdomyosarcoma
• Fibrosarcoma
• Mesenchymoma
• Kaposi’s sarcoma

Sarcoma Cancer Stages

There are four main stages of sarcoma, based on their size and spread:

Stage 1

When the sarcoma is smaller than 5 cm in size and does not spread to the nearby lymph nodes or body parts, it is said to be grade 1a. If the sarcoma is larger than 5 cm and does not spread to the lymph nodes, it is designated as grade 1b sarcoma. It is usually difficult to assess the sarcoma at this stage.

Stage 2

When the sarcoma is around 5 cm or lesser and has not spread to the nearby lymph nodes or other parts of the body, the cancer is said to be grade 2.

Stage 3

When the sarcoma is between 5 cm to 10 cm in size but has not spread to nearby lymph nodes or other parts of the body, it is said to be a grade 3 cancer.

Stage 4

This is an advanced stage of cancer and can be of any size. The cancer cells may have spread to the nearby lymph nodes, and sometimes, even other parts of the body.

Sarcoma Cancer Diagnostic Tests

After evaluating your symptoms, your doctor may conduct a thorough physical examination to check for any lumps or growths. Other diagnostic tests that may be prescribed include the following:

• Imaging Tests: Different imaging tests are available, but cancer doctor will recommend the most suitable one, depending on your condition. X-rays, CT scans, MRI, and PET scans are commonly used imaging tests that give detailed information about the sarcoma's size, nature, and spread.
• Biopsy: If your doctor suspects sarcoma, they may collect a sample of tissue from the affected area and send a laboratory diagnosis to confirm the diagnosis. The tissue sample can also be used to stage and grade the sarcoma after a confirmed diagnosis. A biopsy may sometimes be performed during the surgery to remove cancer.

Sarcoma Cancer Treatment

The treatment options for sarcoma depend upon multiple factors– stage and grade of cancer, spread, and the patient's overall health. The standard cancer treatment options include:

• Surgery: The primary goal of this treatment is to remove the cancer cells.
• Radiation Therapy: High-energy radiation is used to kill cancer cells.
• Chemotherapy: A treatment that uses chemicals or drugs to kill cancer cells.
• Targeted Therapy: A drug therapy that uses medicines that target only cancer cells and eliminate them.
• Ablation Therapy: Heat generated using electricity is used to kill cancer cells.
• Immunotherapy: A form of drug therapy that stimulates the body’s immune system to fight cancer

Sarcoma Cancer Prevention

There are no specific preventive measures to stop one from getting a sarcoma. When someone is at high risk due to genetic or familial history, it may be advisable to undergo routine monitoring to catch the condition early. Reducing risk factors can help reduce the risk of developing sarcoma.

Sarcoma Cancer Complications

Not diagnosing or treating sarcoma in the early stages can spread cancer cells to other parts of the body (a process called metastasis). Advanced-stage sarcomas are challenging to treat and cause different complications in treatments, wound healing, and impact one’s quality of life.

Regardless of the type of sarcoma one has, the goals are early diagnosis, prompt treatment, and symptomatic relief. It is best to speak to the doctor and the multidisciplinary team treating your sarcoma for any queries or concerns one may have.

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