Allogeneic Transplant
Overview
An allogeneic transplant is a procedure in which stem cells for transplantation are collected from a matching donor and transplanted into the patient’s body after high-intensity chemotherapy or radiation. The donor can be a sibling, a relative, or an unrelated person who is an HLA match.
The Allogeneic Transplant Unit at Nanavati Max Super Speciality Hospital is a fully integrated unit offering comprehensive medical, diagnostic, and surgical services to patients suffering from various diseases. The unit is equipped with advanced technology and the latest therapies to treat complex conditions requiring allogeneic transplantation. The team of skilled hematologists and transplant physicians follows a multidisciplinary approach to create a patient-centric treatment plan.
- HLA (Immune)-Match Related Donor (Siblings) Transplant: The bone marrow or stem cells come from the relative of a patient, who is usually a sibling (brother or sister) whose HLA (Histocompatible Leukocyte antigen) matches completely with the patient.
- HLA (Immune)-Matched Unrelated Donor Transplant: The bone marrow or stem cells come from an unrelated donor whose HLA (Histocompatible Leukocyte antigen) matches completely with the patient.
- Haplo Identical Donor Transplant: The bone marrow or stem cells come from HLA (Histocompatible Leukocyte antigen) half-matched (haplotype) donors such as biological parents of the patient or half-matched siblings.
- Umbilical Cord Blood Transplant: Umbilical cord blood cells are collected from a newborn child’s umbilical cord right after birth. These stem cells are very immature so the need for perfect matching is eliminated. The stem cells collected from the cord are frozen and stored until they are used for a transplant.
- The patient’s personal and family medical history are taken and a physical exam may be conducted.
- Lab, imaging and diagnostic tests are performed to ensure the patient is fit for the procedure.
- A central venous catheter may be inserted into a blood vessel to provide the patient with nutrients, fluids, medication and blood
- Eat a protein rich diet, include whole foods in the diet
- Avoid crowds, kids, pets & visitors
- Practise safe food and drink habits
- Wash your hands regularly
- Avoid smoking and tobacco products since it can interfere with the treatment.
- If you have a central venous line or a PICC (Peripherally Inserted Central Catheter), learn how to take care of it
- Ask your doctor about liquid food supplements (if your mouth is sore or dry from the existing medications)
Complications and risks of allogeneic transplant include
- Chest pain
- Drop in blood pressure
- Fever
- Chills
- Headaches
- Hives
- Nausea
- Pain
- Shortness of breath
- Changes in taste
- Anemia
- Graft failure
- Graft v Host Disease (GvHD)
- Infections
- Early menopause
- Delayed growth in children
- Inflammation
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